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Why Does Semaglutide Cause Tiredness? An In-Depth Look at Fatigue

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Introduction

Semaglutide is a powerful medication that has proven effective in managing type 2 diabetes and aiding weight loss in overweight or obese individuals. By mimicking the GLP-1 hormone, semaglutide regulates blood sugar levels and appetite, enhancing insulin secretion, slowing gastric emptying, and reducing hunger.

While semaglutide offers significant benefits, including improved blood sugar control and weight reduction, it may cause side effects. Fatigue is a common issue, which, though seemingly minor, can seriously affect daily life. Understanding and managing this fatigue is crucial for maintaining overall well-being.

Semaglutide, as a GLP-1 receptor agonist, plays a vital role in blood sugar regulation and appetite control. It stimulates insulin release and slows stomach emptying, promoting satiety. However, these mechanisms can also lead to side effects like nausea, vomiting, and fatigue. The fatigue may result from changes in blood sugar levels and metabolic adjustments, especially during the initial stages or dose increases.

To manage fatigue while on semaglutide, consider strategies such as maintaining a nutrient-rich diet to sustain energy levels, drinking plenty of water to stay hydrated, incorporating regular physical activity to boost energy, prioritizing good sleep hygiene, regularly checking your blood sugar levels, and working closely with your healthcare provider to adjust dosages or explore alternative treatments if fatigue persists.

This article provides a comprehensive guide on managing semaglutide-induced fatigue, helping you reap its benefits while maintaining energy and quality of life. Understanding the medication’s effects, recognizing side effects, and implementing practical strategies can lead to a healthier, more energized life.

What is Semaglutide and How Does It Work?

Semaglutide, a GLP-1 receptor agonist, mimics the body’s natural glucagon-like peptide-1 hormone, crucial for regulating blood sugar and appetite.

Mechanism of Action:

  1. Stimulates Insulin Production: Semaglutide enhances insulin secretion from the pancreas when blood sugar levels rise, ensuring glucose is used for energy, thus controlling blood sugar levels.
  2. Reduces Glucagon Release: It lowers glucagon production, preventing excessive sugar release from the liver, stabilizing blood sugar levels.
  3. Slows Stomach Emptying: By slowing gastric emptying, it prolongs satiety, aiding in reduced food intake and promoting weight loss.
  4. Suppresses Appetite: Semaglutide targets brain regions that control hunger, diminishing cravings and supporting weight reduction.

Uses:

  1. Type 2 Diabetes Management: For those with type 2 diabetes, semaglutide boosts insulin production and curtails glucagon release, effectively controlling blood sugar levels and preventing spikes and crashes, thereby reducing fatigue.
  2. Weight Loss: Overweight individuals benefit from semaglutide’s appetite-suppressing and stomach-emptying-slowing effects, facilitating adherence to a calorie-controlled diet. Clinical trials show significant weight loss, reducing risks of heart disease, hypertension, and certain cancers.

Administration:

Semaglutide is administered via subcutaneous injection, available in once-weekly and daily forms. The weekly form is common for diabetes management, while the daily form is typically used for weight loss. Proper administration, as instructed by a healthcare provider, is essential for optimal results.

Side Effects:

Common side effects include nausea, vomiting, diarrhea, and constipation, which generally subside as the body adjusts. Serious side effects, such as hypoglycemia or allergic reactions, require immediate medical attention.

Semaglutide is a potent medication for managing type 2 diabetes and promoting weight loss by mimicking natural hormones to regulate blood sugar and appetite. Understanding its mechanism and potential side effects ensures informed use and maximizes its health benefits.

Understanding Common Side Effects of Semaglutide

Semaglutide, used for type 2 diabetes and weight loss, can cause side effects. Knowing what to expect helps manage them and know when to seek medical help.

Common Side Effects

  1. Nausea: Frequent at the start, usually improves. Manage with smaller meals and avoiding fatty/spicy foods.
  2. Vomiting: Often accompanies nausea, typically decreases. Contact your doctor if severe.
  3. Diarrhea: Can lead to dehydration. Drink plenty of fluids.
  4. Constipation: Increase fiber intake and water to manage.
  5. Abdominal Pain: Ranges from mild to severe, often improves over time.
  6. Headache: Over-the-counter pain relievers can help; consult a doctor if persistent.
  7. Fatigue: Manage with diet, sleep, and hydration.
  8. Dizziness: Usually temporary; seek medical advice if it persists.

Frequency and Severity

  • Nausea/Vomiting: 20-30%
  • Diarrhea/Constipation: 10-20%
  • Abdominal Pain: 5-10%
  • Headaches, Fatigue, Dizziness: Less common but significant

Most side effects are mild to moderate and decrease over time. Monitor symptoms and consult your healthcare provider if needed.

Comparison with Other Medications

  • Liraglutide (Victoza®): Similar side effects, possibly higher nausea/vomiting.
  • Dulaglutide (Trulicity®): Comparable gastrointestinal issues and headaches.

Semaglutide’s side effects are in line with other GLP-1 receptor agonists, but individual responses vary. Discuss with your doctor to find the best option for you.

Action Steps

  1. Monitor Symptoms: Keep track of any side effects.
  2. Communicate with Your Doctor: Report severe or persistent symptoms.
  3. Adjust Diet: Smaller meals, avoid fatty/spicy foods, increase fiber.
  4. Stay Hydrated: Drink plenty of fluids.
  5. Rest and Sleep: Ensure adequate rest to manage fatigue.

Understanding and managing semaglutide’s side effects ensures a more effective treatment experience.

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How Semaglutide Affects Energy Levels

Semaglutide, a GLP-1 receptor agonist, is prescribed to help manage blood sugar levels and promote weight loss. Despite its benefits, some users report experiencing fatigue. Understanding this requires examining how semaglutide functions in the body and its impact on energy levels.

Energy Regulation Basics

Our energy derives from food, broken down into glucose, which fuels our cells. Insulin, produced by the pancreas, facilitates glucose entry into cells. For diabetics, insulin issues prevent proper glucose utilization, leading to high blood sugar and low energy.

Semaglutide’s Mechanism

Semaglutide mimics the hormone GLP-1, enhancing insulin secretion when blood sugar is high, slowing gastric emptying to control appetite, and signaling satiety to the brain, aiding in weight loss. This regulation of blood sugar should ideally boost energy levels, but the reality is more complex.

Blood Sugar Management

By increasing insulin and reducing liver glucose production, semaglutide lowers blood sugar. However, this can sometimes cause hypoglycemia (low blood sugar), especially when combined with other diabetes medications, leading to fatigue, weakness, and dizziness.

Hormonal and Neurological Effects

Semaglutide also alters hormonal and brain pathways. Slowed gastric emptying affects nutrient absorption timing, potentially reducing energy. Changes in brain appetite control can cause fatigue as the body adjusts to new energy dynamics.

Adapting to Semaglutide

Initial use of semaglutide often includes side effects like nausea, vomiting, and fatigue, which typically improve as the body acclimates.

Managing Energy Levels

To manage energy levels while on semaglutide:

  1. Monitor Blood Sugar: Regular checks help prevent extreme highs and lows that sap energy.
  2. Eat Balanced Meals: Regular, balanced meals stabilize energy levels.
  3. Stay Hydrated: Adequate water intake combats fatigue from dehydration.
  4. Exercise Regularly: Moderate activity boosts energy and overall health.

Understanding semaglutide’s impact on energy helps manage fatigue. Collaborating with healthcare providers, monitoring blood sugar, and adopting healthy lifestyle habits can optimize energy levels while benefiting from improved blood sugar control and weight loss.

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Tiredness as a Side Effect of Semaglutide

Tiredness or fatigue is a notable side effect of semaglutide, reported in both clinical trials and real-world user experiences. However, it does not affect everyone uniformly.

Clinical Insights and User Experiences

In clinical trials, like the STEP program for weight loss, around 5-10% of participants reported tiredness. This variability depends on the study population and specific conditions. Online forums also reveal that many users experience fatigue, especially during the initial weeks of treatment. For some, this fatigue diminishes over time, while others may continue to experience it throughout their medication regimen.

Risk Factors for Fatigue

Several factors can increase the likelihood of experiencing tiredness while using semaglutide:

  1. Dosage and Adjustment Period: The body needs time to adjust to semaglutide, and tiredness may be more pronounced during this period, especially with gradual dosage increases.
  2. Individual Health Conditions: Conditions like type 2 diabetes can exacerbate fatigue, particularly as the body adjusts to better-managed blood sugar levels.
  3. Lifestyle Choices: Poor diet, lack of exercise, and inadequate sleep can contribute to fatigue. Conversely, a balanced diet, regular physical activity, and proper rest can help mitigate this side effect.
  4. Hydration Levels: Dehydration can worsen tiredness. Staying well-hydrated is crucial while on semaglutide.

Managing Tiredness

Understanding these factors can help manage fatigue effectively. Monitor your body’s response, maintain a healthy lifestyle, and ensure proper hydration to reduce the impact of tiredness. By doing so, you can make semaglutide a more manageable part of your health regimen.

Understanding Semaglutide and Tiredness

Semaglutide, a medication for managing type 2 diabetes and aiding in weight loss, is known to cause tiredness in many users. Here’s why:

Blood Sugar Levels and Metabolism

Semaglutide controls blood sugar by increasing insulin release and slowing stomach emptying, preventing post-meal spikes. However, overly lowered blood sugar (hypoglycemia) can sap your energy, causing tiredness. If you experience frequent low blood sugar, consult your doctor to adjust your medication or diet.

Hormonal Changes

Semaglutide mimics GLP-1, a hormone that regulates blood sugar and appetite. While beneficial, changes in GLP-1 levels can temporarily cause fatigue as your body adjusts. This adjustment period is usually short-lived.

Nervous System Impact

GLP-1 affects not just blood sugar but also the brain and nervous system, potentially slowing stomach emptying and making you feel sluggish. This side effect might be more noticeable when you first start the medication or increase your dose.

Dehydration

Side effects like nausea, vomiting, and diarrhea from semaglutide can lead to dehydration, which causes tiredness. Stay hydrated with water and electrolyte drinks, and consult your healthcare provider if severe side effects occur.

Medication Adjustment

Feeling tired can be part of your body adjusting to semaglutide. This adjustment period typically improves with time. Rest adequately and avoid overexertion. Persistent or severe tiredness should be discussed with your doctor to rule out other causes.

Semaglutide’s tiredness stems from its effects on blood sugar, hormones, the nervous system, dehydration, and the body’s adjustment process. By understanding these factors, you can better manage and reduce tiredness. Always communicate with your healthcare provider about side effects to ensure optimal care.

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How Long Does Tiredness Last When Taking Semaglutide?

Tiredness is a common side effect when starting semaglutide, impacting many users. Knowing how long this fatigue may last helps manage expectations and routines.

Duration of Fatigue

Initial Phase: Most people feel increased tiredness in the first few days to a couple of weeks as their bodies adjust to semaglutide. This is due to changes in blood sugar levels and metabolism.

Variation: The duration of fatigue varies among individuals. Some might feel tired longer, particularly those sensitive to medication changes. If fatigue persists beyond a few weeks, consult your doctor to ensure it’s a normal side effect and not something more serious.

Expected Improvement

Adaptation Period: Many users notice a decrease in tiredness after the initial adjustment period, typically within four to six weeks. As your body acclimates, energy levels usually improve significantly.

Monitoring: Keep a journal of your medication schedule, daily energy levels, sleep, diet, and exercise. This information is valuable for discussions with your doctor about your symptoms.

Managing Initial Tiredness

Rest: Aim for 7-9 hours of quality sleep each night to support recovery.

Hydration: Drink at least eight glasses of water daily to avoid dehydration, which can worsen fatigue.

Nutrition: Eat balanced meals with fruits, vegetables, whole grains, and lean proteins. Avoid high-sugar and refined carbs to prevent energy crashes.

Exercise: Engage in gentle physical activities like walking or yoga to boost energy and mood.

Self-Care: Listen to your body and rest when needed. Don’t push yourself too hard during the adjustment period.

Avoid Stimulants: Limit caffeine and energy drinks as they can disrupt sleep and increase fatigue.

If these strategies don’t alleviate tiredness, consult your doctor. They may adjust your dosage or suggest other management techniques. Persistent fatigue could indicate a need for further adjustment or highlight an underlying issue.

Tiredness from semaglutide is typically temporary. By understanding its duration and implementing management strategies, you can ease your body’s adjustment to the medication. Keep track of your symptoms and maintain open communication with your healthcare provider to ensure optimal care.

Managing Tiredness While Using Semaglutide: Tips and Strategies

Yes, tiredness can be managed while using semaglutide. Here are some practical tips and strategies to help you feel more energetic and less fatigued.

Lifestyle Changes

Implementing a few daily routine adjustments can significantly reduce tiredness:

  1. Regular Exercise: Engage in at least 30 minutes of light physical activity, like walking or stretching, most days. Exercise enhances blood flow, boosting energy and alertness.
  2. Healthy Diet: Eat a balanced diet rich in fruits, vegetables, whole grains, lean proteins, and healthy fats. Avoid processed foods and sugary snacks, which can lead to energy crashes.
  3. Consistent Sleep Schedule: Maintain a regular sleep routine by going to bed and waking up at the same time every day. This regulates your body’s internal clock, improving sleep quality.

Diet Modifications

What you eat and when you eat can significantly affect your energy levels:

  1. Small, Frequent Meals: Eat smaller meals and healthy snacks throughout the day to stabilize blood sugar levels and prevent energy dips.
  2. Stay Hydrated: Aim for at least 8 cups (64 ounces) of water daily. Increase intake if you exercise or live in a hot climate.
  3. Limit Caffeine and Alcohol: Restrict caffeine to morning hours to avoid sleep disruption. Consume alcohol in moderation or avoid it altogether, as it can interfere with your sleep cycle.

Role of Hydration

Staying well-hydrated is crucial for maintaining energy levels:

  1. Drink Water Regularly: Keep a water bottle with you and take sips often. Don’t wait until you’re thirsty to drink.
  2. Include Hydrating Foods: Eat foods with high water content, such as watermelon, oranges, cucumbers, and lettuce.
  3. Monitor Urine Color: Check your hydration status by observing the color of your urine. Pale yellow indicates good hydration, while darker urine suggests the need for more water.

Sleep Hygiene

Good sleep hygiene can improve sleep quality and reduce tiredness:

  1. Relaxing Bedtime Routine: Wind down with calming activities like reading, listening to soothing music, or taking a warm bath.
  2. Limit Screen Time: Avoid electronic devices at least an hour before bed. The blue light can interfere with sleep.
  3. Sleep-Friendly Environment: Keep your bedroom dark, quiet, and cool. Use blackout curtains, earplugs, or a white noise machine if necessary.
  4. Avoid Heavy Meals Before Bed: Have your last meal 2-3 hours before bedtime to prevent difficulty falling asleep.

Managing Stress

Stress contributes to fatigue, making tiredness harder to manage:

  1. Relaxation Techniques: Practice deep breathing, meditation, or yoga to calm your mind and reduce stress.
  2. Stay Connected: Spend time with friends and family. Talking to someone you trust can be very helpful.
  3. Plan and Prioritize: Create a to-do list and prioritize tasks. Break larger tasks into manageable steps to avoid feeling overwhelmed.

By making these lifestyle changes, modifying your diet, staying hydrated, practicing good sleep hygiene, and managing stress, you can effectively manage tiredness while using semaglutide. Listen to your body and consult your healthcare provider if you experience persistent or severe fatigue. They can offer personalized advice and adjustments to your treatment plan to help you feel your best.

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semaglutide and tiredness 2

When to Consult Your Doctor About Fatigue with Semaglutide

Semaglutide, used for diabetes and weight loss, can sometimes cause fatigue. Understanding when to seek medical advice is crucial. This guide will help you recognize the signs that require a doctor’s attention, communicate effectively with your healthcare provider, and understand potential changes to your treatment.

Warning Signs Requiring Medical Attention

While mild fatigue is common, certain symptoms indicate the need for medical advice:

  • Extreme Fatigue: If tiredness severely impacts your daily activities like getting out of bed, working, or caring for your family, it’s a serious concern.
  • Sudden Onset of Fatigue: Experiencing sudden fatigue after having no issues with semaglutide could signal a change in your body.
  • Additional Symptoms: Fatigue accompanied by dizziness, headaches, nausea, vomiting, or swelling in your hands and feet needs immediate attention.
  • Worsening Fatigue: If fatigue intensifies over time, it may indicate your body isn’t adjusting well to the medication.
  • Impact on Mental Health: Fatigue affecting your mood, causing depression, anxiety, or irritability, warrants a discussion with your doctor.

How to Discuss Fatigue with Your Healthcare Provider

Effective communication with your doctor is essential. Here’s how to prepare for the conversation:

  • Keep a Symptom Diary: Track daily fatigue levels, activities during fatigue, and any other symptoms. This helps your doctor understand your situation.
  • Be Specific: Describe your fatigue clearly. Is it constant or periodic? Does it correlate with medication intake?
  • List All Medications: Inform your doctor about all medications, vitamins, and supplements you take, as interactions can cause fatigue.
  • Ask Questions: Don’t hesitate to seek clarifications. You deserve to understand your health and treatment options fully.

Potential Adjustments to Manage Fatigue

Your doctor may suggest various adjustments:

  • Adjusting Dosage: Lowering the dose of semaglutide can reduce side effects.
  • Changing Timing: Taking medication at a different time, such as in the evening, might reduce daytime fatigue.
  • Switching Medications: If severe fatigue persists, your doctor might recommend an alternative medication.
  • Adding Supplements or Medications: Vitamins, supplements, or additional medications might help boost energy levels.
  • Monitoring and Follow-Up: Regular follow-ups help monitor your condition and make necessary adjustments.

Take Action

Feeling fatigued on semaglutide shouldn’t be ignored. Recognize the warning signs and communicate with your doctor to find relief. Your healthcare provider is there to help you manage symptoms and maintain your health. Don’t hesitate to seek their guidance on any concerns regarding your fatigue.

Alternatives to Semaglutide if Fatigue Persists

If semaglutide’s fatigue is overwhelming, consider other medication options for weight loss and diabetes management. Here’s a look at viable alternatives, their benefits, and drawbacks.

Alternative Medications for Weight Loss

Phentermine: This appetite suppressant stimulates brain chemicals that control hunger. While effective, it can cause increased heart rate, insomnia, and nervousness. It’s usually taken once a day in the morning.

Orlistat (Alli®, Xenical®): Orlistat blocks fat absorption, aiding calorie reduction. Available over-the-counter and by prescription, it often causes gastrointestinal issues like diarrhea and cramps. A low-fat diet is necessary to minimize these side effects.

Liraglutide (Saxenda®): Another GLP-1 receptor agonist, liraglutide slows stomach emptying and reduces appetite. It’s injected like semaglutide but may cause less fatigue. However, nausea and gastrointestinal issues are still possible.

Naltrexone-Bupropion (Contrave®): This combination medication reduces hunger and cravings by targeting brain regions regulating appetite and energy use. Side effects can include nausea, headache, and dizziness.

Alternative Medications for Diabetes Management

Metformin: Commonly prescribed for type 2 diabetes, metformin reduces sugar production by the liver and improves insulin response. It can cause gastrointestinal issues, particularly when starting.

Sulfonylureas (e.g., Glipizide, Glyburide): These drugs increase insulin production and are taken before meals. They are effective but can cause low blood sugar and weight gain.

DPP-4 Inhibitors (e.g., Sitagliptin [Januvia®], Saxagliptin [Onglyza®]): These medications boost insulin production and reduce sugar release by the liver, with a low risk of low blood sugar. Side effects may include respiratory infections and headaches.

SGLT2 Inhibitors (e.g., Canagliflozin [Invokana®], Empagliflozin [Jardiance®]): These drugs help the kidneys remove excess sugar through urine, aiding in weight loss and lowering blood pressure. However, they can increase the risk of urinary tract infections and dehydration.

Evaluating Medication Switches

Switching medications might reduce semaglutide-induced fatigue. However, each medication comes with its own side effects and risks. What works for one person might not be suitable for another.

Always consult your healthcare provider before changing medications. They can help you weigh the pros and cons based on your health needs and goals. They may also suggest adjusting your current dose or combining treatments to manage side effects effectively.

If semaglutide is causing significant tiredness, several alternative medications are available. Discuss these options with your healthcare provider to find the best solution tailored to your situation.

Conclusion

Understanding why semaglutide causes tiredness requires examining its mechanisms and effects on the body. Semaglutide, used for weight loss and diabetes management, mimics the GLP-1 hormone, regulating blood sugar, slowing digestion, and reducing appetite. While effective, these actions can also lead to tiredness.

Common side effects include nausea, vomiting, diarrhea, and constipation. Notably, many users experience fatigue, ranging from mild to severe, which can hinder daily activities. This tiredness stems from complex factors, including blood sugar regulation and metabolic changes. Low blood sugar levels can cause fatigue, and altered nutrient absorption and hormonal changes also contribute.

Clinical trials and user reports confirm that fatigue is a prevalent side effect, impacting many users. This can be challenging for those managing weight loss or diabetes, as it affects their ability to stay active and healthy. Individual health, dosage, and duration of use influence the severity of fatigue.

The exact mechanisms behind semaglutide-induced tiredness are not fully understood, but key factors include blood sugar control and digestive slowdown. Tight blood sugar control can lead to hypoglycemia, causing fatigue, while slower digestion can result in sluggishness.

Fatigue duration varies; some experience temporary tiredness, while others may have prolonged fatigue. Patience is crucial as the body adjusts. Managing fatigue involves rest, balanced nutrition, hydration, and good sleep hygiene.

If fatigue is severe or persistent, consulting a doctor is essential. A healthcare provider can determine if semaglutide or other factors cause fatigue and may adjust the dosage or suggest alternatives.

For those struggling with persistent fatigue, alternative medications for weight loss and diabetes management exist. Each has different side effects, and healthcare providers can help find the best fit based on individual health needs.

Understanding and managing semaglutide-induced tiredness ensures users can benefit from the medication. Individualized treatment and open communication with healthcare providers are vital for successfully managing fatigue and maintaining health.

Research Citations

Marso SP, Bain SC, Consoli A, et al. “Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes.” New England Journal of Medicine, vol. 375, no. 19, 2016, pp. 1834-1844.

Davies MJ, Bergenstal R, Bode B, et al. “Efficacy of Liraglutide for Weight Loss Among Patients With Type 2 Diabetes: The SCALE Diabetes Randomized Clinical Trial.” JAMA, vol. 314, no. 7, 2015, pp. 687-699.

Aroda VR, Saugstrup T, Buse JB, et al. “Efficacy and Safety of Once-Weekly Semaglutide Versus Exenatide ER in Subjects With Type 2 Diabetes (SUSTAIN 3).” Diabetes Care, vol. 39, no. 2, 2016, pp. 231-241.

Pratley RE, Aroda VR, Lingvay I, et al. “Semaglutide Versus Dulaglutide Once Weekly in Patients With Type 2 Diabetes (SUSTAIN 7): A Randomised, Open-Label, Phase 3b Trial.” Lancet Diabetes Endocrinol, vol. 6, no. 4, 2018, pp. 275-286.

Nauck MA, Petrie JR, Sesti G, et al. “A Phase 2, Randomized, Dose-Finding Study of the Novel Once-Weekly Human GLP-1 Analog Semaglutide in Subjects with Type 2 Diabetes.” Journal of Diabetes and its Complications, vol. 29, no. 8, 2015, pp. 1231-1238.

Newsome PN, Buchholtz K, Cusi K, et al. “A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis.” New England Journal of Medicine, vol. 384, no. 12, 2021, pp. 1113-1124.

Mosenzon O, Blicher TM, Rosenlund S, et al. “Efficacy and Safety of Oral Semaglutide in Patients With Type 2 Diabetes and Moderate Renal Impairment (PIONEER 5): A Placebo-Controlled, Randomised, Phase 3a Trial.” Lancet Diabetes Endocrinol, vol. 9, no. 6, 2021, pp. 405-417.

Husain M, Birkenfeld AL, Donsmark M, et al. “Oral Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes.” New England Journal of Medicine, vol. 381, no. 9, 2019, pp. 841-851.

Armstrong MJ, Gaunt P, Aithal GP, et al. “Liraglutide Safety and Efficacy in Patients With Non-alcoholic Steatohepatitis (LEAN): A Multicentre, Double-Blind, Randomised, Placebo-Controlled Phase 2 Study.” Lancet, vol. 387, no. 10019, 2016, pp. 679-690.

Zinman B, Aroda VR, Buse JB, et al. “Efficacy, Safety, and Tolerability of Oral Semaglutide Versus Placebo Added to Insulin With or Without Metformin in Patients With Type 2 Diabetes: The PIONEER 8 Trial.” Diabetes Care, vol. 44, no. 6, 2021, pp. 1470-1481.

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Questions and Answers: Semaglutide and Tiredness

Yes, tiredness can be a side effect of semaglutide. Some users report feeling fatigued or experiencing low energy levels while taking this medication.

The exact reason why semaglutide may cause tiredness is not fully understood. However, it could be related to changes in blood sugar levels, the body’s adjustment to the medication, or individual metabolic responses.

Tiredness is not the most common side effect of semaglutide, but it has been reported. The frequency can vary depending on the individual and their overall health condition.

Yes, tiredness can often be managed by ensuring adequate hydration, maintaining a balanced diet, getting regular exercise, and adjusting the timing of the medication under a doctor’s guidance.

You should not stop taking semaglutide without consulting your healthcare provider. They can help determine if the tiredness is due to the medication and suggest ways to manage it or consider alternative treatments.

Yes, other side effects like nausea, vomiting, and gastrointestinal discomfort can also lead to tiredness. Managing these symptoms may help reduce overall fatigue.

The dosage of semaglutide can impact side effects, including tiredness. Higher doses might increase the likelihood of experiencing fatigue. Your healthcare provider can adjust your dosage if necessary.

The duration of tiredness can vary. Some people may experience it for a short period as their body adjusts to the medication, while others might feel tired for a longer duration. Monitoring and reporting this to your doctor is important.

Yes, lifestyle changes such as regular physical activity, healthy eating, staying hydrated, and ensuring adequate sleep can help reduce tiredness associated with semaglutide.

Yes, it is important to report any side effects, including tiredness, to your healthcare provider. They can provide personalized advice and make any necessary adjustments to your treatment plan.

Jay Flottman

Dr. Jay Flottman

Dr. Jay Flottmann is a physician in Panama City, FL. He received his medical degree from University of Texas Medical Branch and has been in practice 21 years. He is experienced in military medicine, an FAA medical examiner, human performance expert, and fighter pilot.
Professionally, I am a medical doctor (M.D. from the University of Texas Medical Branch at Galveston), a fighter pilot (United States Air Force trained – F-15C/F-22/AT-38C), and entrepreneur.

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